Page 97 - MEMOCiberesp014-ENG

• DM-2, Obesity, Metabolic Syndrome, Hyperlipidemia, Cardiovascular Risk . - We investigate the role of vitamin D in the prevention of DM and the MS (one PhD Thesis already ended in 2013) .
• Endocrinology of Reproduction (Diabetes and Thyroid) . - Monogenic diabetes and pregnancy . Inves- tigation of the prevalence of MODY-2 and 3, as well as fetomaternal morbidities . / Gestation and Diabetes . Research activities involving macrosomia, influences of race, and adaptative changes of therapeutic insulin regimens .
Most relevant scientific articles
• gonzÁlez C., aulinas a., ColoM C., tunDiDor D., MenDoza l., CorCoy r. et al . Thyroglobulin as early prognos- tic marker to predict remission at 18-24 months in differentiated thyroid carcinoma . Clinical Endocrinology . 2014;80(2):301-306 .
• Vinagre i., sÁnChez-quesaDa J.l., sÁnChez-hernÁnDez J., santos D., orDonez-llanos J., De leiVa a. et al . Inflammatory biomarkers in type 2 diabetic patients: Effect of glycemic control and impact of ldl subfraction phenotype . Cardiovascular Diabetology . 2014;13(1) .
• haWa M.i., kolB h., sChloot n., Beyan h., PasChou s.a., Buzzetti r. et al . Adult-onset autoimmune diabetes in Europe is prevalent with a broad clinical phenotype: Action LADA 7 (Diabetes Care (2013) 36, (908-913) . Dia- betes Care . 2014;37(5):1494 .
• Mato e., gonzÁlez C., Moral a., Pérez J.i., Bell o., lerMa e. et al . ABCG2/BCRP gene expression is related to epithelial-mesenchymal transition inducer genes in a papillary thyroid carcinoma cell line (TPC-1) . Journal of Molecular Endocrinology . 2014;52(3):289-300 .
• aulinas a., raMírez M.-J., Barahona M.-J., Valassi e., resMini e., Mato e. et al . Telomere length analysis in Cushing’s syndrome . European Journal of Endocrinology . 2014;171(1):21-29 .
Highlights
Institution: Instituto de Investigación del Hospital de la Santa Cruz y San Pablo Contact: Inst . de Investigación del Hospital de la Sta . Cruz y San Pablo . C/ . S Antoni Ma Claret 167 . 08025 Barcelona · E-mail: aleiva@santpau .cat
• ENDOCRINE CANCER . In our research on differentiated thyroid carcinoma (DTC ) we recorded serum bank and private collection of 200 tumors .We have discovered by proteomics the involvement of genes (ABCG2/ BCRP, VDAC2 ) in epithelial-mesenchymal transition processes, undifferentiation and aggressiveness, and differential expression of 120 proteins (2D-DIGE) in these tumors . We have published that the determina- tion of basal thyroglobulin may predict remission of DTC . We have shown that PGLA nanoparticles loaded with the chemotherapy agent inhibitor of tyrosine kinase are recognized by monoclonal antibodies against VEGFR-FGFR in human poorly DTC cell lines (potential therapeutic target) . We evaluated telomerase activity in Cushing’s syndrome, demonstrating the beneficial effect of treatment on processes associated with aging .
• DIABETES, OBESITY, DYSLIPIDEMIA AND BIOMEDICAL TECHNOLOGY. We have observed, for the first time, by ultrasound, preclinical atherosclerosis markers (vascular intima-media thickness, IMT) at different stages of gestation, finding a relationship between gestational age and IMT in the umbilical artery, and between BMI and IMT in the maternal common carotid artery . We have completed and published the immunological, metabolic and clinical characterization of diabetes LADA in the Spanish population (EU Project) . A Doctoral Thesis – PhD candidate Irene Vinagre – demonstrated the impact of glycemic control on inflammation bio- markers and LDL-c . The technological platform PREDIRCAM, CIBER-BBN original, is being subject to a Spanish multicenter clinical trial (3 university hospitals-FIS) .
• FUNDED RESEARCH PROJECTS. The projects DALI (Prevention of Gestational Diabetes in Europe) and CON- CEPTT (first clinical trial worldwide about the continuous monitoring of glycemic control in pregnancy; we are Co-IP and members of the Steering Committee) keep going, as well as national projects (with GBT-UPM), investigating open/ closed loop and semi-automation of insulin therapy . In 2014, we were granted the SGR 2014-16 with maximum score (6 .66/7 .0) of those obtained by the IIB-HSP .
www .ciber-bbn .es 97