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RESEARCH GROUPS
Endocrinology and Diabetes Research Group
Programme: Bioengineering and Medical Imaging
Lead Researcher: Leiva Hidalgo, Alberto Group Members
STAFF MEMBERS: Bell Ramírez, Olga Lidia | Mato Matute, Ma Eugenia ASSOCIATED MEMBERS: Chico Ballestero, Ana Isabel | Corcoy Pla, Rosa CONTRIBUTORS: Cubero Marcos, Jose María | González Blanco, Cintia
Main lines of research
THYROID CANCER . • Markers of prognostic prediction . Implication of 21 genes in CDT . Development of data base, and a
private collection of serum and tissue bank of epithelial thyroid cancer (more of 200 cases) . We found the relationship between the expression of ABCG2/BRCP transporter gen and the aggressiveness of the TPC-1human cell-line of thyroid cancer . We have identified differential hyper-and under-expres- sion of genes in PTC and FTC . 120 proteins have been identified by proteomic analysis .
• In vitro and in vivo evaluation of a an original thyroid chemotherapy . PGLA nanoparticles, loaded with an inhibitor of tyrosinkinase, recognize the neoplastic cells by a monoclonal antibody against EGFR .
DIABETES MELLITUS, METABOLIC SYNDROME, OBESITY, CARDIOMETABOLIC RISK . • Autoimmune Diabetes Mellitus . EU Research Consortium that has characterized the genetics, the im-
munology, the metabolic and the clinical phenotype of LADA in 11 european countries .
• Telemedicine and Intelligent Systems for the Therapeutical Optimization of Diabetes Mellitus: PRE- DIRCAM Project . Original technological platform of CIBER-BBN, previously validated; at present, a multicentric clinical trial is being developed in 3 Spanish University Hospitals . (Coordination, EDUAB- HSP) / CONCEPTT: Continuous Glucose Monitoring (CGM) in Women with Type 1 Diabetes in Preg- nancy Trial . First worldwide clinical trial to demonstrate the benefits of CGMS in diabetic pregnancy . EDUAB-HSP is a Member of the Steering Committee too (countries involved: Canada, Israel, Italy, Spain USA) . / DALI Project: Lifestyle intervention in the prevention of Gestational Diabetes (GDM) . It is a EU Research Project (7th Framework) . / Telemedicine and Intelligent Systems for Therapeutic Op- timization of Diabetes Mellitus . Investigation of combined open and closed loop systems to achieved normoglycemia in type 1 diabetes .
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CIBER-BBN » Annual report 2014