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Most relevant scientific articles
• uroseViC J., garCía-alBéniz X., Planet e., real s., CesPeDes M.V., guiu M. et al . Colon cancer cells colonize the lung from established liver metastases through p38 MAPK signalling and PTHLH . Nature Cell Bio- logy . 2014;16(7):685-694 .
• CésPeDes M.V., unzueta u., tatkieWiCz W., sÁnChez-CharDi a., ConChillo-sole o., alaMo P. et al . In vivo archi- tectonic stability of fully de novo designed protein-only nanoparticles . ACS Nano . 2014;8(5):4166-4176 .
• De la torre C., CasanoVa i., aCosta g., Coll C., Moreno M.J., alBeriCio F. et al . Gated mesoporous silica nanoparticles using a double-role circular peptide for the controlled and target-preferential release of doxorubicin in CXCR4-expresing lymphoma cells . Advanced Functional Materials . 2014 .
• unzueta u., saCCarDo P., DoMingo-esPin J., CeDano J., ConChillo-sole o., garCía-Fruitós e. et al . Sheltering DNA in self-organizing, protein-only nano-shells as artificial viruses for gene delivery . Nanomedicine: Nanotechnology, Biology, and Medicine . 2014;10(3):535-541 .
• alaMo P., gallarDo a., PaVón M.a., CasanoVa i., trías M., Mangues M.a. et al . Subcutaneous precon- ditioning increases invasion and metastatic dissemination in mouse colorectal cancer models . DMM Disease Models and Mechanisms . 2014;7(3):387-396 .
Highlights
Institution: Instituto de Investigación del Hospital de la Santa Cruz y San Pablo Contact: Instituto de Investigación del Hospital de la Santa Cruz y San Pablo S Antoni Ma Claret 167 . 08025 Barcelona · Tel .: (+34) 93 553 79 18 · E-mail: rmangues@santpau .cat Web: http://www .iibsantpau .cat
The continuity of the NanoMets CIBER-BBN intramural Project of Excellence has been approved . We have obtained funding from Fundació La Marató de TV3 for this project, which is carried out in collaboration with Antonio Villaverde and Ramon Eritja groups and focuses on the development of a targeted genotoxic nanoconjugate as antimetastatic drug for colorectal cancer . The renewal fo the recognition of our Group as Consolidated has been granted by the Generalitat de Catalunya AGAUR agency . We have become members of the COST Action (EU-RTD) on antitumor resistance and cancer stem cells and of the European Technology Platform on Nanomedicine (EATRIS) in the area of advanced therapies and Biologicals . The CIBER-BBN Nanotoxicology Unit coordinated by our group has been incorporated to the NANBIOSIS Platform, which has been recognized as singular ICTS by the Spanish MINECO, having also obtained a contract for an infrastructure support technician associated with this Unit . In collaboration with Roger Gomis, of the Institut de Recerca Biomédica in Barcelona we have identified the molecular mechanism of re-metastasis from liver to lung in colorectal cancer . In collaboration with Villaverde’s group we have demonstrated stability and long re-circulation time in the bloodstream of the nanoparticles we are using for targeted drug delivery . The researcher Lourdes Farré and its post-doctoral fellow Marcelo Magalhaes, from the FIOCRUZ Center at Salvador de Bahia (Brasil), have performed a stage in our laboratory to complete a join bilateral project . We have obtained a Sara Borrell post- doctoral contract and defended one doctoral dissertation . We have also been granted a US patent on focal adhesion inhibitors as antitumor drugs . Our Group continues its industrial transference activity through contracts with the pharmaceutical industry for the preclinical development of new antitumor drugs within an INNPACTO project of the Spanish MINECO .
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