Page 57 - MEMOCiberesp014-ENG

different sources can be cultured on these materials using different flow conditions allowing the manipulation of cell behavior as a function of physical stimulation, and mimicking the physiological conditions .
The chamber is made of a transparent material allowing the visualization of cultured cells by microscopic techniques . Furthermore, the chamber is hermetically sealed thereby keeping controlled conditions .
The present invention has application in the tissue engineering field, as well as for the characterization of the cell response to a wide range of biocompatible materials .
HAPTENS, ANTIBODIES, AND METHOD TO DETECT PSEUDOMONAS AERUGINOSA INFECTIONS
Spanish Patent Application P201330312
International Patent Application PCT/ES2014/070161
The present invention is related to the design of haptens, structurally related to pyocyanin, a toxin secreted by the Gram negative bacterium Pseudomonas aeruginosa, and its derivatives . It is also related to the hapten conjugates used for the production of specific antibodies against such substances . Furthermore, the invention refers to a method and a kit for the detection and quantification of pyocyanin and its derivatives, using the mentioned antibodies, to detect infections due to Pseudomonas aeruginosa .
FIBRIN HYDROGELS WITH PLASMONIC NANOPARTICLES
Spanish Patent Application P201330894
International Patent Application PCT/ES2014/070484
The invention relates to a photothermal device comprising plasmonic nanoparticles embedded in a hydrogel made of fibrin matrix that in addition may entrap thermosensitive effectors . Irradiation of the device with near infrared light of specific wavelength and energy level increases the temperature of the composite . This photothermal device can be implanted and then irradiated on demand, providing a reliable source of heat in biological tissues . Localized photothermia can be used to remotely control the delivery of therapeutic agents from the device . The invention is useful for the application of hyperthermia-based therapies and controlled delivery of therapeutic agents in biological tissues .
METHOD FOR DIRECT COVALENT ANCHORING OF NUCLEIC ACIDS TO SOLID STANDS
Spanish Patent Application P201331587
International Patent Application PCT/ES2014/070813
Development of efficient superficial chemical functionalization for the production of DNA microarrays on solid stands has become essential for the improvement of DNA chip technology .
The present invention is related to a method for the superficial chemical activation of a silicon base solid stand by means of direct covalent anchoring of oligonucleotides, with no use of crosslinkers or catalysts . To date, chips where oligonucleotides and stand surface are directly linked without intermediary have not been reported . The product obtained by this method is the first one .
The invention focuses on the use of click chemistry reactions to both immobilize covalently and spatially locate nucleic acid probes on a silicon base stand . Also it focuses on the method to modify these probes in order to allow the anchoring .
INTELLIGENT BIO-IMPEDANCE SENSOR FOR BIOMEDICAL APPLICATIONS
Spanish Patent Application P201301062
International Patent Application PCT/ES2014/070822
It is a portable sensor that measures bio-impedance in a part of the body, an organ, a tissue or a fluid, allowing continuous monitoring of physiological variables and health condition .
www.ciber-bbn.es 57