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CIBER-BBN » Annual report 2014
refers to the biomaterial itself obtainable by the procedure of the invention . A third aspect of the present invention refers to the use of the biomaterial for the manufacture of an implant or biomedical device, such as dental or orthopaedic implant, knee, shoulder, or elbow prostheses .
PROCEDURE TO SHAPE THE SURFACE OF CURABLE MATERIALS
Spanish Patent ES 2370690 B2
Lens, optical cavities, and curve mirrors, from millimetric to nanometric size, to be apply in industries such as optic, photonic, electronic, communication, optoelectronic, etc .
Cell cultures substrates: Substrates topographically modified have shown a better cellular behaviour, improving adhesion, growth or differentiation .
Chemical and biochemical micro-reactors: Confinement systems, from millimetric to nanometric size, for processes requiring space restrictions, such as crystallization, chemical or biochemical reactions, biological, cellular or bacterial systems, etc . microchips and micro-arrays, for biology, biochemistry, medicine, biotechnology, etc .
ANTIBODIES FOR THE DETECTION AND QUANTIFICATION OF ANTICOAGULANTS
Spanish Patent Application P201231836
International Patent Application PCT/ES2013/070816
The present invention is related to the design of haptens structurally related to oral coumarin-like anticoagulants, (CAC) in order to be used for the production of specific antibodies against such substances . Furthermore, to be used for the development of point-of care (PoC) devices . Particularly, a diagnostic tool has been developed for the quantification of plasma levels of CAC in treated patients .
CELL CULTURE DEVICE
Spanish Patent Application P201230911
International Patent Application PCT/ES2013/000141
The present invention refers to an encapsulated device (lab-on-chip) useful to study cell cultures . It is preferably made of a plastic material where several culture wells are located . Bottoms of wells are covered with a gelled material, differing from mechanical properties in each well . The objective of the invention is the production of high throughput analytical systems capable of studying the cellular response depending on the gelled substrate rigidity .
MICRO-CHAMBER DEVICE FOR CELLULAR CULTURE MONITORING BY NUCLEAR MAGNETIC RESONANCE
Spanish Patent ES2365282B1
The present invention comprises a micro-chamber device for cell culture allowing longitudinal long-term monitoring of the cellular system by nuclear magnetic resonance (NMR) and other image techniques . Image analysis and metabolic studies can be performed .
Effect of active agents, such as drugs, nanoparticles or biological factors, can be assessed . By using it, a better knowledge of physiological and pathological conditions will be acquired, helping for diagnosis and therapy .
CHAMBER DEVICE FOR DYNAMIC CELL CULTURE ON BIOMATERIALS
Spanish Patent Application P201330040 International Patent Application PCT/ES2013070819 This new device is composed by a chamber where 2D or 3D biomaterials can be immobilized . Cells from