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NEW DELIVERY SYSTEM OF THERAPEUTICS TO COLORECTAL CANCER CELLS
European Patent Application EP2011382005.4 International Patent Application PCT/EP2012/050513 National phase in Europe, USA, Japón, China, India, Australia, and Israel
A new drug delivery system for the selective treatment of colorectal tumor cells has been developed . So far, in vivo delivery tests have been successful, showing specific and receptor mediated cell internalization of payload vehicles in tumor and metastasis tissues at low doses .
Furthermore, carriers have shown high stability into the animal, without apparent toxicity .
OCULAR DEVICE
Spanish Patent ES 2370014 B2 International Application PCT/ES2012/070474 US Application number 13/534,583
The present invention describes a device useful for retinal re-attachment and its post-surgery treatment . It belongs to the micro- and nano-technologies for health and biomedical applications, particularly to the optimization of ophthalmological surgery, as well as to patient post-surgery conditions .
The device, provided by this invention, keeps the retinal hole closed and improves the well-being of patient after surgery . Its components are intra-ocularly injected and placed in the tear zone closing the retinal holes causing the detachment .
It was tested in rabbits . Results showed a 90% success in the retina re-attachment after one week . Furthermore, no side effects have been detected .
The high incidence of retinal detachment places this pathology as a priority for ophthalmologists, particularly the technological challenge of achieving an efficient system to close the break due to retinal hole .
OPTIMIZED HISTOLOGICAL METHOD FOR THE PRESERVATION OF EPITOPES AND CELLULAR ARCHITECTURE OF VERTEBRATE TISSUES
Spanish Patent ES 2363551 B2
This invention develops an optimized new method for the histological and histochemical preservation of tissue . This method is compatible with any staining method for histological sections, as well as for immuno-localization and in situ hybridization .
The optimization with respect to the present techniques is achieved by the combination of fixing and inclusion conditions, and the use of the appropriate chemicals and materials for fixation and inclusion, allowing a very high preservation of the morphology and reactive properties of the tissue . Sections have been processes for immuno-staining and in situ hybridization, and the results compared with control techniques . The method in this invention improves most of the present histological methods designed for optical microscopy, and constitutes a good alternative to classical histological methods .
PROCEDURE FOR OBTAINING A BIOMATERIAL WITH METALLIC COATING
Spanish Patent ES 2372340 B1
The present invention refers to a procedure for obtaining a biomaterial with biocompatible metallic coating, by means of a metallurgic method . Besides, the present invention refers to the use of this biomaterial for medical applications .
A first aspect of the present invention refers to a procedure for obtaining the biomaterial, the parameters influencing the final properties of the biomaterial and coating . The parameters are optimized according to the desired final composition and properties of the material . A second aspect of the present invention
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