Page 58 - MEMOCiberesp014-ENG

The sensor is in contact with the biological environment to be measured through four electrodes, in a way that both, injects electrical current inside the biological environment and measures the tension produced by the said current circulation . It is capable of taking bio-impedance measurements for multiple frequencies, processing data to obtain both magnitude and phase of bio-impedance for every frequency, and transmitting the results wirelessly, according to the whole operation of the (1) sensing, (2) processing data, (3) wireless communication, (4) timing (5) data storage, and (6) energy subsystems .
This device is useful in the areas of mHealth, eHealth, information and communications technology, biomedical engineering and medical technology .
BIOREACTOR FOR CELL CO-CULTURE
European Patent Application EP14157145.5
The invention relates to a cell co-culture bioreactor comprising at least first and second cell culture chambers, said chambers being separated by a porous membrane for cell culture . Said membrane forms a single part with its sealing gasket which, in turn, defines a closed perimeter demarcating a first cell culture area .
The bioreactor can bring together several membranes parallel to one another to form additional culture chambers . In this invention the concept of “cell co-culture” is not limited to two different cell types but rather relates to two, three or more cell types . The bioreactor allows the separate analysis of each cultured cell type, in addition to the paracrine influence between them .
The bioreactor is compact, versatile and allows cell co-culture in an easy and simple manner, optimising both cultured cell viability and the time required for conducting assays .
DEVICE FOR MEASURING TRANSCELLULAR ELECTRICAL IMPEDANCE IN IN VITRO CELL BARRIER MODELS
European Patent Application EP14170509.5
Cell (endothelial or epithelial) barrier dysfunction is a characteristic of a number of diseases . A common technique for quantitatively evaluating cell barrier integrity without affecting cell physiology is based on the study of passive electrical properties of cells . Measuring transcellular electrical impedance provides a quantifiable value of the state of the barrier .
The present invention allows studying different in vitro cell barrier models by means of a device comprising two chambers, where cells are cultured, and an interdigitated electrode array on the inner surfaces of the chambers . It also comprises elements for the electrical connection to an impedance measurement apparatus and to an electroporation apparatus .
BIOACTIVE GLASS AND SCAFFOLDS, METHODS OF PREPARATION AND USES THEREOF
Spanish Patent Application P201400570
This invention relates to bioactive materials for being used in biomedical technologies for tissue regeneration and engineering . It particularly relates to bioactivo glass and to three-dimensional networks or bioactive glass scaffolds . Furthermore, the invention relates to methods of preparation and to uses thereof in regeneration, particularly in bone tissue engineering .
The primary objective of this invention is the design and preparation of a new bioactivo glass that is able to provide active biological signals to favour cell adhesion, migration, proliferation and differentiation by creating better cell stimuli and a better capability of detecting biological needs or changes in the environment .
58 CIBER-BBN » Annual report 2014