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med through the supervision of doctoral theses (more than 15 theses read) or the giving of courses to PhD students and specialized technical personnel .
From a practical point of view, the research group is interested in and develops projects in the following areas:
1 .Cardiovascular Diseases 2 .Infectious Diseases 3 .Neurologic and Neurodegenerative Diseases 4 .Therapeutic Drug Monitoring 5 .Adverse Drug Reactions
Most relevant scientific articles
• Valera e., garCía-FeBrero r., PiViDori i., sÁnChez-Baeza F., MarCo M.-P. Coulombimetric immunosensor for paraquat based on electrochemical nanoprobes This work is dedicated to the memory of Dr . Francisco Sánchez-Baeza . Sensors and Actuators, B: Chemical . 2014;194:353-360 .
• garCía-FeBrero r., salVaDor J.-P., sÁnChez-Baeza F., MarCo M.-P. Rapid method based on immunoassay for determi- nation of paraquat residues in wheat, barley and potato . Food Control . 2014;41(1):193-201 .
• FernÁnDez F., PinaCho D.g., grataCos-CuBarsi M., garCía-regueiro J.-a., Castellari M., sanChez-Baeza F . et al . Immu- nochemical determination of fluoroquinolone antibiotics in cattle hair: A strategy to ensure food safety . Food Chemistry . 2014;157:221-228 .
• PinaCho D.g., sÁnChez-Baeza F., PiViDori M.-i., MarCo M.-P. Electrochemical detection of fluoroquinolone antibiotics in milk using a magneto immunosensor . Sensors (Switzerland) . 2014;14(9):15965-15980 .
• esteBan-FernÁnDez De aVila B., CaMPuzano s., PeDrero M., salVaDor J.-P., MarCo M.-P., Pingarron J.M. Lipoprotein(a) determination in human serum using a nitrilotriacetic acid derivative immunosensing scaffold on disposable electrodes . Analytical and Bioanalytical Chemistry . 2014;406(22):5379-5387 .
Highlights
Institution: Agencia Estatal Consejo Superior de Investigaciones Científicas Contact: Instituto de Química Avanzada de Cataluña, CSIC . C/ Jordi Girona, 18-26 . 08034 Barcelona . E-mail: nb4d@iqac .csic .es · Website: www .iqac .csic .es/nb4d
Nb4D continues to work on the development of diagnostic devices to be used in the clinical field as well as the food safety and environmental monitoring fields .
In collaboration with Pharmasans Labs Inc . (USA) the group developed immunoreagents against neurotransmit- ters of interest in neurodegenerative and neurological disorders . Specifically, the group has developed antibodies against neurotransmitters derived from the phenylalanine patways such as the catecholamines, adrenaline and noradrenaline .
Other neurotransmitters have been developed during this collaboration and are being exploited in the project TryKySeNS (CTQ2011-29163-C03-01) . An ELISA has been validated for kynurenic acid, a neuroprotector involved in neurological disorders . The assay has been tested on real samples from patients suffering Alzheimer’s and from healthy controls using cerebrospinal fluid and plasma provided by the 12 de Octubre Hospital in Madrid . The results are promising and Nb4D hopes to be able to design a point-of-care biosensor device .
In the area of infectious disease detection the group has continued their studies on the detction of bacteria such as Pseudomonas aeruginosa (pycocyanin, a toxin produced by the bacteria) and Staphylococcus aureus . The assays have been tested on samples of plasma and sputum from patients . The group has applied to the Spanish Patents Office to patent the immunoreagents it has developed to detect pyocyanin and has received interest from various companies and research groups .
The group is also developing immunoreagents against biomarkers of interest in cardiovascular diseases . The hope is to be able to develop a point-of-care device that can be used to determine the stage of cardiac disease that the patient is at . These studies are part of the NanoCardioCoco project (IPT2001-1337-010000) whose objective is work with enterprises to translate the research results into viable products for the benefit of society as a whole .
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