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Most relevant scientific articles
• Díez P., sÁnChez a., gaMella M., Martínez-ruiz P., aznar e., De la torre C. et al . Toward the design of smart delivery systems controlled by integrated enzyme-based biocomputing ensembles . Journal of the American Chemical Society . 2014;136(25):9116-9123 .
• Mas n., arCos D., Polo l., aznar e., sÁnChez-salCeDo s., sanCenón F. et al . Towards the development of smart 3D “gated scaffolds” for on-command delivery . Small . 2014; 10(23):4859-4864 .
• giMénez C., CliMent e., aznar e., MartÁnez-Manez r., sanCenón F., MarCos M.D. et al . Towards chemical communication between gated nanoparticles . Angewandte Chemie - International Edition . 2014; 53(46):12629-12633 .
• De la torre C., MonDragon l., Coll C., sanCenon F., MarCos M.D., Martínez-Manez r. et al . Cathepsin-B induced controlled release from peptide-capped mesoporous silica nanoparticles . Chemistry - A Euro- pean Journal . 2014; 20(47):15309-15314 .
• Moragues M.e., tosCani a., sanCenón F., Martínez-Manez r., White a.J.P., Wilton-ely J.D.e.t . A chromo- fluorogenic synthetic “canary” for CO detection based on a pyrenylvinyl ruthenium(II) complex . Jour- nal of the American Chemical Society . 2014; 136(34):11930-11933 .
Highlights
Institution: Universidad Politécnica de Valencia Contact: Centro de Reconocimiento Molecular y Desarrollo Tecnológico . Camino de Vera s/n, Edificio 5M . 46022 Valencia · Teléfono: (+34) 96 387 73 43 E-mail: idm@upv .es · Website: idm .webs .upv .es
During 2014, we started with activities in the Intramural Projects NANOHYPERTERMIA, NEURO-MON, TBIO-GATE SPRING and NANOSENFIBRO and in the transfer project MICHORMON-PRO . We have also continued with the ECO EXOLUNG project . Within all these projects, we have prepared a collection of new gated materials for controlled release applications and as sensors . A part from continuing our current regional and National Plan projects, in 2014 we have been granted with an EXPLORA project related with the development of probes for biomolecules using gating mechanisms and also with two seed projects to establish collaborations with Hospital “La Fe” about new detection systems of prostate cancer using multiplatform analysis of urine samples and the theranostic application of nanoparticles in experimental ischemic ictus .
Also this year, we have continued with an intense scientific activity publishing over thirty-three articles in international journals of high impact factor . In these works we have demonstrated that it is possible to develop systems that chemically communicate using gated nanoparticles, or in collaboration with the group of María Vallet, that our delivery systems can be integrated in three-dimensional matrices or scaffolds .
At the international level, we have participated in the preparation of various European projects propo- sals . In addition, we hosted five PhD students from India, United States, Netherlands, United Kingdom and a postdoctoral from India . In addition, two of our PhD students have spent several months in Ire- land and Italy .
Finally, in 2014 our group has participated in the CIBER-BBN training program being granted with three scholarships and six students have defended their PhD thesis during this year .
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