Page 99 - MemoriaBBN-Eng
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- DALI Project: Lifestyle intervention in the prevention of Gestational Diabetes (GDM).
It is a EU Research Project (7th Framework).
- Telemedicine and Intelligent Systems for Therapeutic Optimization of Diabetes Melli-
tus. Investigation of combined open and closed loop systems to achieved normoglyce-
mia in type 1 diabetes.
• DM-2, Obesity, Metabolic Syndrome, Hyperlipidemia, Cardiovascular Risk.
- We investigate the role of vitamin D in the prevention of DM and the MS (one PhD
Thesis already ended in 2013).
•
Endocrinology of Reproduction (Diabetes and Thyroid).
- Monogenic diabetes and pregnancy. Investigation of the prevalence of MODY-2 and 3,
as well as fetomaternal morbidities.
- Gestation and Diabetes. Research activities involving macrosomia, influences of race,
and adaptative changes of therapeutic insulin regimens.
• J JG, P mn, G s, d G, C r, d r .. DALI: Vitamin
Most relevant elsmAvAn oPPelAlJAArdesoyeorCoyevlieGeret Al
D and lifestyle intervention for gestational diabetes mellitus (GDM) prevention: an Eu-
scientific ropean multicentre, randomised trial - study protocol.BMC Pregnancy Childbirth. 2013
articles
Jul 5;13:142.
á
• hAWA mi, KolB h, sChloot n, BeyAn h, PAsChou sA, Buzzetti r et Al.. Adult-onset autoimmune í
diabetes in Europe is prevalent with a broad clinical phenotype: Action LADA 7.Diabetes
Care. 2013 Apr;36(4):908-13.
• mollo A, hernndez m, mArsAl Jr, esquerdA A, rius F, BlAnCo-vACA F et Al.. Latent autoimmu-
ne diabetes in adults is perched between type 1 and type 2: evidence from adults in one
region of Spain.Diabetes Metab Res Rev. 2013 Sep;29(6):446-51.
• AulinAs A, rAmrez mJ, BArAhonA mJ, mAto e, Bell o, surrAllés J et Al.. Telomeres and endo-
crine dysfunction of the adrenal and GH/IGF-1 axes.Clin Endocrinol (Oxf). 2013 Aug 12;.
• THYROID NEOPLASMS. A) The creation of a private collection of tissue samples and a
Highlights
serum bank of more than 200 patients with thyroid neoplasms, adequately character-
ized, recorded in the Endocrine Tumors Committee, Hospital de Sant Pau, chaired by
the Principal Investigator. B) The results obtained in the transcriptomic and proteomic
analysis in a cohort of 160 patients with epithelial thyroid carcinoma, suggesting the
hyperexpression of genes TWIST1 and ANLN as new markers of undifferentiation and
metastasis. C) The identification of a set of 120 proteins with a differential pattern
between healthy thyroid, adenoma and thyroid epithelial carcinoma (papers invited to
the International Congress on Thyroid Cancer, and to the American Association of Clini-
cal Endocrinology). D) Original observation of the relationship between the expression
of gene ABCG2/BCRP1 and the aggressiveness of a human cell line (CP-1) of thyroid
follicular cancer, with loss of expression of NIS (regulatory gene of iodine uptake), of
clinical importance in refractory cancer to I-131 treatment.
• DIABETES MELLITUS. Completion, within the European Project Action LADA, of a re- 13
á20
search activity coordinated (A.de Leiva) with the Hospital Universitario de Lérida (Di- T
dac Mauricio), that determines, for the first time, the prevalence and clinical, metabolic OR
P
and immunological characterization of diabetes type LADA in Spain. Twelve per cent of éRE
patients initially diagnosed with DM-2 should be classified as DM-LADA, with a more L
A
severe metabolic alteration than classical DM-2 and early need for insulin therapy.
NU
N
• INTERNATIONALIZATION. A. de Leiva named: A) Honorary Member of the Romanian A
Society of Diabetes, B) International Evaluator, Chair of Endocrinology of the Univer- N /
B
sity of Cluj-Napoca, C) Member of the International Honorary Committee for the in- -B
auguration of the Chair in History of Medicine, University of Yucatn (Mrida, Mexico). R
BE
A.de Leiva and R.Corcoy D) were named members of the Steering Committee, Inter- CI
national Project CONCEPTT-JDRF, that for the first time is going to analyse the benefits 99
of Continuous Glucose Monitoring (CGM) during pregnancy in women with DM-1.
