Page 101 - MemoriaBBN-Eng

www.ciber-bbn.es

• P C, C mv, l mB, K s, m A, e Ph .. STC1
Most relevant eñAésPedesindhiFlemAriAmezheyeusKidqvistet Al
expression by cancer-associated fibroblasts drives metastasis of colorectal cancer.
scientific Cancer Res. 2013 Feb 15;73(4):1287-97.

articles
• unzuetA u, sACCArdo P, dominGo-esPín J, CedAno J, ConChillo-solé o, GArCíA-Fruitós e et
Al.. Sheltering DNA in self-organizing, protein-only nano-shells as artificial viruses

for gene delivery.Nanomedicine. 2013 Nov 21;.

• BosCh r, moreno mJ, diéGuez-González r, CésPedes mv, GAllArdo A, triAs m et Al.. A novel
orally available inhibitor of focal adhesion signaling increases survival in a xenograft

model of diffuse large B-cell lymphoma with central nervous system involvement.
Haematologica. 2013 Aug;98(8):1242-9.

• r CW, m C, A m, l-P A, W C, A dP .. A phase II
yAnAtiAsGulniKóPezousAilliAmsde lWiset Al
study of tasisulam sodium (LY573636 sodium) as second-line or third-line treatment
for patients with unresectable or metastatic soft tissue sarcoma.Invest New Drugs.

2013 Feb;31(1):145-51.

• de JuAn J, GArCíA J, lóPez m, orús C, esteller e, quer m et Al.. Inclusion of extracapsular

spread in the pTNM classification system: a proposal for patients with head and neck
carcinoma.JAMA Otolaryngol Head Neck Surg. 2013 May;139(5):483-8.

We have obtained a new project from the Instituto de Salud Carlos III for the
Highlights
development of animal models of colorectal cancer to study tumor relapse, and

participated in a European Union COST Action on Hypoxia. We demonstrated se-
lective biodistribution to CXCR4+ tumor and metastatic cells of a nanoconjugate

that links the T22 nanoparticle to a fluoro-pyrimidine after intravenous adminis-

tration in a metastatic colorectal cancer model, in collaboration with Villaverde’s
and Eritja’s group. The increased concentration of the antitumor agent achieved

in tumor tissue increases the number of DNA double strand breaks and apop-
totic figures, leading to a significant reduction in CXCR4+ cells in tumor tissue.

In collaboration with Arne Ostman (Karolinska Instituet) we demonstrated that

PDGF-stimulated tumor-associated fibroblasts secrete SCT1, a glycoprotein that
potentiate metastasis development in a colorectal cancer model. We have also

developed a diffuse large B-cell Lymphoma model with central nervous system

(CNS) involvement and demonstrated the capacity of an inhibitor of focal adhe-
sion signalling in inhibiting metastatic growth in the CNS. We have also identified

Rab25, a regulator of intracellular membrane trafficking, as a prognostic marker
in head and neck squamous cell carcinoma patients. We have extended the pa-

tent we hold on nanoparticles targeting CXCR4-expressing cells to Europe, USA,

Japan, China, Israel, India and Australia. We defended two doctoral dissertations
and two visiting researchers form Brasil stayed in our laboratory during 2013. We

continue our translational and industrial activities by carrying out contract work
13
for the Pharmaceutical Industry in preclinical drug development using biolumines- 20
cent orthotopic models derived from lentivirus-transduced cancer cell lines.
T
OR
P
RE
L
A
NU
N
A
N /
B
-B
R
BE
CI

101