Page 60 - MemoriaBBN-Eng

TECHNOLOGICAL OFFER

The present invention is related to the design of haptens, structurally related to pyo-

cyanin, a toxin secreted by the Gram negative bacterium Pseudomonas aeruginosa,
and its derivatives. It is also related to the hapten conjugates used for the production

of specific antibodies against such substances. Furthermore, the invention refers to a

method and a kit for the detection and quantification of pyocyanin and its derivatives,
using the mentioned antibodies, to detect infections due to Pseudomonas aeruginosa.

• FIBRINHYDROGELSWITHPLASMONICNANOPARTICLES

Spanish Patent Application P201330312

International Patent Application PCT/ES2014/070161

The invention relates to a photothermal device comprising plasmonic nanoparticles

embedded in a hydrogel made of fibrin matrix that in addition may entrap thermosen-
sitive effectors. Irradiation of the device with near infrared light of specific wavelength

and energy level increases the temperature of the composite. This photothermal de-

vice can be implanted and then irradiated on demand, providing a reliable source of
heat in biological tissues. Localized photothermia can be used to remotely control the

delivery of therapeutic agents from the device. The invention is useful for the applica-

tion of hyperthermia-based therapies and controlled delivery of therapeutic agents in
biological tissues.

• METHODFORDIRECTCOVALENTANCHORINGOFNUCLEICACIDSTO

SOLID STANDS

Spanish Patent Application P201331587

Development of efficient superficial chemical functionalization for the production of
DNA microarrays on solid stands has become essential for the improvement of DNA

chip technology.

The present invention is related to a method for the superficial chemical activation of a

silicon base solid stand by means of direct covalent anchoring of oligonucleotides, with
no use of crosslinkers or catalysts. To date, chips where oligonucleotides and stand

surface are directly linked without intermediary have not been reported. The product
obtained by this method is the first one.

The invention focuses on the use of click chemistry reactions to both immobilize cova-

lently and spatially locate nucleic acid probes on a silicon base stand. Also it focuses

on the method to modify these probes in order to allow the anchoring.

• INTELLIGENTBIO-IMPEDANCESENSORFORBIOMEDICALAPPLICATIONS

Spanish Patent Application P201301062

It is a portable sensor that measures bio-impedance in a part of the body, an organ, a tissue 13
20
or a fluid, allowing continuous monitoring of physiological variables and health condition.
T
R
The sensor is in contact with the biological environment to be measured through four PO
E
electrodes, in a way that both, injects electrical current inside the biological environment L R
and measures the tension produced by the said current circulation. It is capable of tak- A
NU
ing bio-impedance measurements for multiple frequencies, processing data to obtain both N
A
magnitude and phase of bio-impedance for every frequency, and transmitting the results /
wirelessly, according to the whole operation of the (1) sensing, (2) processing data, (3) BN
B
wireless communication, (4) timing (5) data storage, and (6) energy subsystems.
R-
BE
This device is useful in the areas of mHealth, eHealth, information and communications CI
technology, biomedical engineering and medical technology.

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