Page 58 - MemoriaBBN-Eng

TECHNOLOGICAL OFFER

The optimization with respect to the present techniques is achieved by the combination

of fixing and inclusion conditions, and the use of the appropriate chemicals and materi-
als for fixation and inclusion, allowing a very high preservation of the morphology and

reactive properties of the tissue. Sections have been processes for immuno-staining and

in situ hybridization, and the results compared with control techniques. The method in
this invention improves most of the present histological methods designed for optical

microscopy, and constitutes a good alternative to classical histological methods.

• PROCEDUREFOROBTAININGABIOMATERIALWITHMETALLICCOATING

Spanish Patent ES 2372340 B1

The present invention refers to a procedure for obtaining a biomaterial with biocompat-
ible metallic coating, by means of a metallurgic method. Besides, the present invention

refers to the use of this biomaterial for medical applications.

A first aspect of the present invention refers to a procedure for obtaining the biomate-

rial, the parameters influencing the final properties of the biomaterial and coating. The
parameters are optimized according to the desired final composition and properties of

the material. A second aspect of the present invention refers to the biomaterial itself

obtainable by the procedure of the invention. A third aspect of the present invention
refers to the use of the biomaterial for the manufacture of an implant or biomedical

device, such as dental or orthopaedic implant, knee, shoulder, or elbow prostheses.

• PROCEDURETOSHAPETHESURFACEOFCURABLEMATERIALS

Spanish Patent ES 2370690 B2

Lens, optical cavities, and curve mirrors, from millimetric to nanometric size, to be ap-
ply in industries such as optic, photonic, electronic, communication, optoelectronic, etc.

Cell cultures substrates: Substrates topographically modified have shown a better cel-

lular behaviour, improving adhesion, growth or differentiation.

Chemical and biochemical micro-reactors: Confinement systems, from millimetric to

nanometric size, for processes requiring space restrictions, such as crystallization,
chemical or biochemical reactions, biological, cellular or bacterial systems, etc. micro-

chips and micro-arrays, for biology, biochemistry, medicine, biotechnology, etc.

• ANTIBODIESFORTHEDETECTIONANDQUANTIFICATIONOF
ANTICOAGULANTS

Spanish Patent Application P201231836

International Patent Application PCT/ES2013/070816

The present invention is related to the design of haptens structurally related to oral
13
coumarin-like anticoagulants, (CAC) in order to be used for the production of specific 20
T
antibodies against such substances. Furthermore, to be used for the development of R
point-of care (PoC) devices. Particularly, a diagnostic tool has been developed for the PO
E
quantification of plasma levels of CAC in treated patients.
L R
A
NU
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• CELLCULTUREDEVICE
A
/
Spanish Patent Application P201230911
BN
B
International Patent Application PCT/ES2013/000141
R-
BE
The present invention refers to an encapsulated device (lab-on-chip) useful to study CI

cell cultures. It is preferably made of a plastic material where several culture wells are
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located. Bottoms of wells are covered with a gelled material, differing from mechani-