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cal properties in each well. The objective of the invention is the production of high

throughput analytical systems capable of studying the cellular response depending
on the gelled substrate rigidity.

• MICRO-CHAMBERDEVICEFORCELLULARCULTUREMONITORINGBY

NUCLEAR MAGNETIC RESONANCE

Spanish Patent ES2365282B1

The present invention comprises a micro-chamber device for cell culture allowing
longitudinal long-term monitoring of the cellular system by nuclear magnetic reso-

nance (NMR) and other image techniques. Image analysis and metabolic studies

can be performed.

Effect of active agents, such as drugs, nanoparticles or biological factors, can be
assessed. By using it, a better knowledge of physiological and pathological condi-

tions will be acquired, helping for diagnosis and therapy.

• SYSTEMFORCONTROLLEDDELIVERYOFPROTEINSAND
THERAPEUTIC USE

Spanish Patent Application P201031933

International Patent Application PCT/IB2011/055928

The invention refers to a system for transportation and controlled delivery of proteins.

The first aspect of this invention refers to a complex to be used as carrier and con-

trolled delivery systems. Particularly for proteins and targeted to endothelial cell ly-

sosomes. A second aspect of the invention is the manufacturing process of these
complexes in a simple way avoiding the use of both, organic solvent and extreme

conditions, which could damage the protein structure. The third aspect is the use of

these complexes to prepare drug in order to treat diseases, particularly, those due to
enzyme disorders.

This system protects the protein structure against denaturalization in the blood flow

and increases the protein efficacy through a controlled delivery in the specific cellular
compartment.

• CHAMBERDEVICEFORDYNAMICCELLCULTUREONBIOMATERIALS

Spanish Patent Application P201330040

International Patent Application PCT/ES2013070819

This new device is composed by a chamber where 2D or 3D biomaterials can be

immobilized. Cells from different sources can be cultured on these materials using

different flow conditions allowing the manipulation of cell behavior as a function of 13
physical stimulation, and mimicking the physiological conditions.
20
T
The chamber is made of a transparent material allowing the visualization of cultured OR
P
cells by microscopic techniques. Furthermore, the chamber is hermetically sealed RE
thereby keeping controlled conditions.
L
A
The present invention has application in the tissue engineering field, as well as for NU
N
the characterization of the cell response to a wide range of biocompatible materials.
A
N /
B
-B
• HAPTENS,ANTIBODIES,ANDMETHODTODETECTPSEUDOMONAS R
AERUGINOSA INFECTIONS
BE
CI
Spanish Patent Application P201330312

59
International Patent Application PCT/ES2014/070161