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ENIAC-2012-120215) and through contracts with companies. The output of this scientific
activity has been reflected in an increasing number of publications (more than 160 scientific

publications in high impact international journals), participation in international confer-
ences, patents and scientific training activities performed through the supervision of doc-

toral theses (more than 15 theses read) courses to PhD students and specialized technical
personnel.

From a practical point of view, the research group is interested and develops projects in the
following areas

1. Cardiovascular Diseases

2. Infectious Diseases

3. Neurologic and Neurodegenerative Diseases

4. Therapeutic Drug Monitoring
5. Adverse Drug Reactions

• A A, s n, l s, m mP, r F. Bond elasticity controls molecular re-
Most relevant lemAnyAnviCensde orenzoArCoitort
cognition specificity in antibody-antigen binding.Nano Lett. 2013 Nov 13;13(11):5197-202.
scientific
• Conzuelo F, CAmPuzAno s, GAmellA m, PinACho dG, revieJo AJ, mArCo mP et Al.. Integrated dispo- á
articles sable electrochemical immunosensors for the simultaneous determination of sulfonamide

and tetracycline antibiotics residues in milk.Biosens Bioelectron. 2013 Dec 15;50:100-5.

• esteBAn-Fernndez de ávilA, BertA esCAmillA-Gómez, vAnessA CAmPuzAno, susAnA Pedrero, mAríA
s, J. P m, m. P; P, J m.. Ultrasensitive amperometric mag-
AlvAdorABloArCoilArinGArrónosé
netoimmunosensor for human C-reactive protein quantification in serumSENSOR ACTUAT
B-CHEM. 2013;188:212-220.

• m A, P dG, C v, d Jm, G B, s s .. A portable electro-
uriAnoinAChohABottAuXiserensrAnierteAdet Al
chemical magnetoimmunosensor for detection of sulfonamide antimicrobials in honey.Anal á
Bioanal Chem. 2013 Sep;405(24):7885-95.

• v e, m A, P i, s-B F, m mP. Development of a Coulombimetric
AlerAuriAnoividorinChezAezAArCo
immunosensor based on specific antibodies labeled with CdS nanoparticles for sulfonamide
antibiotic residues analysis and its application to honey samples.Biosens Bioelectron. 2013

May 15;43:211-7.

Among the most important results achieved during 2013, are the development of seve-
Highlights
ral diagnostic systems for cardiac biomarkers as result of our participation in projects of
industrial orientation at European (ENIAC: CAJAL4EU) and National level (INNPACTO:

Nanocardiococco). Furthermore, we have been able to develop electrochemical nanopro-
bes resulting from labeling of antibodies with metal nanoparticles, which allows us to

increase performance of the amperometric biosensors. The use of electrochemical nano-
probes offers significant advantages over enzymatic labeling, improving detectability and

shortening the analysis time.

From the point of view of transference and translation activities, it is worth mentioning 13
the patent (PCT/ES2014070161) protecting the knowledge related to the production of 20
antibodies to a specific biomarker of Pseudomonas aeruginosa, which have been used T
OR
to develop an immunochemical method for the detection of infections caused by this P
microorganism. In this context, we have held discussions with various companies and RE
L
a collaborative project (NanobioSepRes) between CIBERES, separ and CIBER-BBN,has A
initiated which aims to conduct a study on the clinical utility of this biomarker and immu- NU
N
nochemical techniques developed. It is also noteworthy, the renewal of research contracts A
with companies Unisensor SA (Belgium) and Pharmasan (USA), with whom the group N /
B
collaborates in the development of diagnostic methods for improving food security, and -B
for the diagnosis of disorders neurological. In the same line, mention the operating agree- R
BE
ment signed with the company Coorporation Bioo Scientific (USA).
CI

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