Page 105 - MemoriaBBN-Eng

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• C e, m l, m-m r, s F, m md, m Jr ..
Most relevant limentondrAGónArtínezáñezAnCenónArCosurGuíAet Al
Selective, highly sensitive, and rapid detection of genomic DNA by using gated mate-
scientific rials: Mycoplasma detection.Angew Chem Int Ed Engl. 2013 Aug 19;52(34):8938-42.

articles
• Coll C, BernArdos A, mArtínez-máñez r, sAnCenón F. Gated silica mesoporous sup-
ports for controlled release and signaling applications.Acc Chem Res. 2013 Feb

19;46(2):339-49.

• mAs n, GAliAnA i, mondrAGón l, AznAr e, Climent e, CABedo n et Al.. Enhanced efficacy
and broadening of antibacterial action of drugs via the use of capped mesoporous

nanoparticles.Chemistry. 2013 Aug 19;19(34):11167-71.

• AznAr e, villAlonGA r, Giménez C, sAnCenón F, mArCos md, mArtínez-máñez r et Al.. Glu-
cose-triggered release using enzyme-gated mesoporous silica nanoparticles.Chem

Commun (Camb). 2013 Jul 21;49(57):6391-3.

• orovAl m, Climent e, Coll C, eritJA r, Aviñó A, mArCos md et Al.. An aptamer-gated
silica mesoporous material for thrombin detection.Chem Commun (Camb). 2013 Jun

18;49(48):5480-2.

Highlights
In this year, we have continued our participation in the Intramural projects NA-
NOCOMETS, MICHORMON, NANOHYPERTERMIA, and BIO-GATES. Within all this

projects, we have prepared a collection of new gated materials for controlled re-
lease and sensing applications.

We have had an intense scientific activity during 2013 reporting more than thirty

publications in international journals of high impact factor. We can highlight the

preparation of new gated nanoparticles for the selective, highly sensitive, and ra-
pid detection of genomic DNA (Angew. Chem. Int. Ed. 2013, 52, 8938). The deve-

loped innovative strategy for the detection of DNA sequences, is able to compete
with classical methods which need PCR amplification, in important areas, such as

point-of-care diagnostics or detection of specific biological contaminations with

pathogens. Such comparatively simple and cheap yet highly selective and sensiti-
ve assays hold promise for use in less-developed areas of the world.

Moreover, we have also developed an aptamer-gated silica mesoporous material

for thrombin detection in collaboration with Ramon Eritja’s group (Chem. Com-

mun. 2013, 49, 5480). The method, based on a simple competitive procedure, is
undemanding and suggests that the use of aptamers can be a suitable approach

to develop gated nanoparticles for simple chromo-fluorogenic assays for a wide
range of bio-applications.

Finally, in 2013 our group has participated in the CIBER-BBN training program

with two grants for initiation in research. Moreover, Alessandro Agostini, Inmacu-

lada Campos, Yolanda Salinas and Tatiana Abalos have defended their PhD thesis
during this year.
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