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rray and RNAseq), metabolomics, glycolytic flux balance analysis and integrative data analysis . The goals are the identification of new biomarkers of tumor progression, tested on human samples, and new therapeutic targets, validated by RNAi or specific drugs, with emphasis on metabolic regulators that are differentially activated in metastatic CSCs or non-CSCs .
• MONITORING CONVENTIONAL TUMOUR THERAPY . The non invasive imaging platform permits the measu- rement of tumour response to therapeutic strategies during time, in the same experimental animal, impro- ving data consistency and reproducibility, as well as, savings in animal resources .
Most relevant scientific articles
• aguilar e., Bago J.r., soler-BotiJa C., alieVa M., rigola M.a., Fuster C. et al . Fast-Proliferating adipose tissue mesenchymal-stromal-like cells for therapy . Stem Cells and Development . 2014;23(23):2908-2920 .
• Vila o.F., Martino M.M., neBuloni l., kuhn g., Pérez-aMoDio s., Muller r. et al . Bioluminescent and micro- computed tomography imaging of bone repair induced by fibrin-binding growth factors . Acta Biomateria- lia . 2014;10(10):4377-4389 .
• reyes D., Ballare C., Castellano g., soronellas D., Bago J.r., BlanCo J. et al . Activation of mitogen-and stress- activated kinase 1 is required for proliferation of breast cancer cells in response to estrogens or progestins . Oncogene . 2014;33(12):1570-1580 .
• haBel n., Vilalta M., BaWa o., oPolon P., BlanCo J., FroMigue o. Cyr61 silencing reduces vascularization and dissemination of osteosarcoma tumors . Oncogene . 2014 .
• CuenCa-lóPez M.D., anDraDes J.a., góMez s., zaMora-naVas P., gueraDo e., ruBio n. et al . Evaluation of poste- rolateral lumbar fusion in sheep using mineral scaffolds seeded with cultured bone marrow cells . Interna- tional Journal of Molecular Sciences . 2014;15(12):23359-23376 .
Highlights
Institution: Agencia Estatal Consejo Superior de Investigaciones Científicas Contact: Instituto de Química Avanzada de Cataluña, CSIC . C/ Jordi Girona, 18-26 . 08034 Barcelona E-mail: jeronimo .blanco@iqac .csic .es http://www .iqac .csic .es/index .php?option=com_ogngrups&view=detall_ grup&Itemid=95&cid=72&lang=es
The Cell Therapy Group is involved in two general aspects of cell therapy: regenerative medicine and cell based tumor therapy, as well as, in the advancement of our understanding of the interactions between stem cells and tumor cells . The main advances of the team during 2014 were: in cell therapy, the completion of the work characterizing a new cell type, “Fast Proliferating Mesenchymal Stem Cells” (FP-MSCs) derived from human mesenchymal cells from adipose tissue (hAMSCs), whit a replication capacity 3,5 fold faster than that of the parental type . Such cells are expected to be useful in therapeutic strategies requiring large numbers of cells . In tumor therapy, it has been shown that FP-MSCs expressing HSV thymidin kinase have a capacity equivalent to that of hAMSCs for bystander killing of tumors . Moreover, a project showing that the repeated application of FP-MSCs is able to “chronify” or keeps inhibited, a glioblastoma tumor implanted in the mouse brain . In support of our hypothesis that hAMSCs nest in the tumor vascular system, more precisely, in the tumor stem cell niche, we have completed a project showing that the selective elimination of CD133+ tumor stem cells is sufficient to inhibit a tumor of human glioma implanted in the brain of an immune depressed mouse .
During 2014 the research team has been supported by a project from MINECO, the Cell Therapy Network “TerCel” and an internationalization project with India for the use of photodynamic therapy against tumors . Additional support has been provided by a “Retos Colaboración” project with Instituto Químico de Sarria and the SAGETIS company .
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