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TECHNOLOGICAL OFFER
Following the process for protecting inventions, abstracts were prepared with non-confidential information of these patent applications, updating the technological offer of the CIBER-BBN:
DELIVERY OF SUBSTANCES TO SENESCENT CELLS
Spanish Patent Application P201231370
International Patent Application PCT/ ES2013/070581
This invention refers to nanodevices for controlled and specific delivery of substances (drugs, bio-actives, markers, cosmetics) to senescent cells . The nanodevice comprises a carrier enclosing the cargo and allowing its liberation when targeted cells are reached, by means of the interaction with senescence- associated beta-galactosidase (SA-ß-Gal) . Therefore, it is useful for senescence studies, prevention and treatment of senescent-associated diseases . Besides others where ß-Gal is specifically present or increased .
The invention also comprises preparation procedures and uses of the nanodevice . The invention belongs to the pharmaceutical and cosmetic fields .
FUNCTIONALIZED LIPOSOMES USEFUL FOR THE DELIVERY OF BIOACTIVE COMPOUNDS
Licensed patent International Patent Application PCT/EP2013/063646 National phase in Europe, USA, Japan, China, Russia and Brazil
The present invention is related to a new kind of functionalized liposome, for the selective delivery of active agents . This liposome carries a conjugate, by means of functionalizing the sterol present in its lipid bi-layer with a polymer, linked by a no-carbamate bond (differing from the state of the art) . Besides, the polymer is also functionalized with a guiding ligand . This conjugate improves the physical-chemical properties of its carrying vesicles, making these more stable and homogeneous . A procedure for their preparation, a pharmaceutical composition containing these liposomes, and their therapeutic use are described as well .
AMPHIPHILIC COPOLYMERS WITH ANTITUMORAL PROPERTIES
Spanish Patent Application P201230679
International Patent Application PCT/ES2013070287
The present invention describes the use of a family of amphiphilic co-polymers that form micro- or nano- micelles, with intrinsic anti-tumoral activity, and also serving as vehicles for other anti-tumoral agents .
BIOMIMETIC PEPTIDE AND ITS USE AS OSTEOGENIC FACTOR
Spanish Patent ES 2417705 B1
International Patent Application PCT/ES2013/000007
The present invention comprises a peptide with osteogenic capacity, the sequence of nucleotides codifying for this peptide, as well as a genetic construction containing said sequence, a vector containing said construction or sequence, and a host cell containing this vector . The invention also comprises the use of the peptide, or its pharmaceutical compositions, for bone regeneration or coating of implants and prostheses .
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CIBER-BBN » Annual report 2014