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Most relevant scientific articles
• CésPeDes M.V., unzueta u., tatkieWiCz W., sÁnChez-CharDi a., ConChillo-sole o., alaMo P. et al . In vivo ar- chitectonic stability of fully de novo designed protein-only nanoparticles . ACS Nano . 2014;8(5):4166- 4176 .
• seras-Franzoso J., tsiMBouri P.M., Burgess k.V., unzueta u., garCía-Fruitos e., Vazquez e. et al . Topogra- phically targeted osteogenesis of mesenchymal stem cells stimulated by inclusion bodies attached to polycaprolactone surfaces . Nanomedicine . 2014;9(2):207-220 .
• unzueta u., saCCarDo P., DoMingo-esPin J., CeDano J., ConChillo-sole o., garCía-Fruitos e. et al . Sheltering DNA in self-organizing, protein-only nano-shells as artificial viruses for gene delivery . Nanomedicine: Nanotechnology, Biology, and Medicine . 2014;10(3):535-541 .
• seras-Franzoso J., PeeBo k., garCia-Fruitos e., VÁzquez e., rinas u., VillaVerDe a. Improving protein delivery of fibroblast growth factor-2 from bacterial inclusion bodies used as cell culture substrates . Acta Bio- materialia . 2014;10(3):1354-1359 .
• PesarroDona M., Ferrer-Miralles n., unzueta u., gener P., tatkieWiCz W., aBasolo i. et al . Intracellular targeting of CD44+ cells with self-assembling, protein only nanoparticles . International Journal of Pharmaceutics . 2014;473(1-2):286-295 .
Highlights
Institution: Universidad Autónoma de Barcelona Contact: Instituto de Biotecnología y Biomedicina . Universidad Autónoma de Barcelona . Campus Universitario . 08193 Bellaterra-Cerdanyola del Vallés · Teléfono: (+34) 93 581 30 86 E-mail: Antoni .Villaverde@uab .cat · http://ibb .uab .cat/ibb/index .php?option=com_wrapper&Itemid=127
In close collaboration with Profs Ramón Mangues and Simó Schwartz, the group has developed functio- nal protein nanoparticles for targeted therapy in colorectal and breast cancers, which are stable in vivo and that escape renal clearance . These features dramatically increase the circulation time thereof and its bioavailability, and it allows the accumulation of these vehicles and their cargos in target tissues, with a very effective biodistribution .The group also designs and produces diverse functional nanostructured materials , mainly based on proteins, for various therapeutic and regenerative medicine purposes . This is achieved in collaboration with other CIBER groups and with external groups .These activities are carried out through the following projects:
• Personalized nanomedicine for triple negative breast cancer stem cells. TV32013-133930. E. Vazquez. 2013-16 .
• Vehicle and cargo engineering in non- viral gene therapy of metastatic colorectal cancer. PI12/00327. E . Vazquez . 2013-16 .
• Optimization period of dry cow by protein nanoparticles. RTA2012-00028-C02-02. E. García. 2013-16.
• Functionalized nanoliposomes for the development of therapies for intracellular-based diseases. Appli- cation to Fabry disease and homozygous familial hypercholesterolemia . (Lipocell) . JL . Corchero . 2014- 15 . Developing therapies for the treatment of rare congenital metabolic diseases (TERARMET) . JL . Corchero . 2014-16 .
• Genotoxic nanoparticles targeting colorectal cancer stem cells . TV32013-132031 . A . Villaverde . 2014-16 .
• ENGINEERING OF PROTEIN NANOPARTICLES FOR Targeted DELIVERY of THERAPEUTIC PROTEINS AND NUCLEIC ACIDS . BIO2013-41019-P . A . Villaverde . 2014-16 .
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