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Most relevant scientific articles
• Martín-saaVeDra F.M., CeBriÁn V., góMez l., lóPez D., arrueBo M., Wilson C.g. et al . Temporal and spa- tial patterning of transgene expression by near-infrared irradiation . Biomaterials . 2014;35(28):8134- 8143 .
• Frutos e., alVarez D., FernÁnDez l., gónzalez-CarrasCo J.l. Effects of bath composition and processing conditions on the microstructure and mechanical properties of coatings developed on 316 LVM by hot dipping in melted AlSi alloys . Journal of Alloys and Compounds . 2014;617:646-653 .
• salDana l., CresPo l., BensiaMar F., arrueBo M., VilaBoa n. Mechanical forces regulate stem cell response to surface topography . Journal of Biomedical Materials Research - Part A . 2014;102(1):128-140 .
• CalzaDo-Martin a., CresPo l., salDana l., Bore a., góMez-Barrena e., VilaBoa n. Human bone-lineage cell responses to anisotropic Ti6Al4V surfaces are dependent on their maturation state . Journal of Biome- dical Materials Research - Part A . 2014;102(9):3154-3166 .
• BraCeras i., PaCha-oliVenza M.a., CalzaDo-Martin a., Multigner M., Vera C., BronCano l.l .- . et al . De- crease of Staphylococcal adhesion on surgical stainless steel after Si ion implantation . Applied Surface Science . 2014;310:36-41 .
Highlights
Institution: Servicio Madrileño de Salud Contact: Hospital La Paz . Paseo de la Castellana, 261 . 28046 Madrid . Teléfono: (+34) 91 207 10 34 E-mail: nuria .vilaboa@salud .madrid .org Website: http://www .idipaz .es/PaginaDinamica .aspx?IdPag=300&Lang=EN
The group of Bone Physiopathology and Biomaterials has performed a thorough characterization of se- veral modifications of polymers and 316 LVM steel and Ti64 alloys, including analyses of thermolectrical and mechanical behaviour as well as biocompatibility tests . The group has progressed in the develop- ment of gene switches for the spatial and temporal regulation of the expression of therapeutic trans- genes, which have been adapted to control osteogenic and angiogenic proteins in tissue engineering applications . Furthermore, the ability of focused ultrasounds and near-infrared irradiation to activate these switches has been demonstrated . Moreover, the group has studied the influence of mechanical stimulation on human cells cultured on biomedical alloys . The clinical scientists of the group have con- tinued their participation in clinical trials for therapeutical interventions in bone-related diseases . The group funded its activities by means of grants from MINECO, ISCIII and research contracts with the industry .
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