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• X y, n e, s-m i, G t, s K, o d .. Directed diffe-
Most relevant iAivetAnChoArtínezAlleGosuzuKiKAmurAet Al
rentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells.Nat
scientific Cell Biol. 2013 Dec;15(12):1507-15.

articles
• zhAnG K, liu Gh, yi F, montserrAt n, hishidA t, rodríGuez esteBAn C et Al.. Direct con-
version of human fibroblasts into retinal pigment epithelium-like cells by defined

factors.Protein Cell. 2013 Jun 20;.

• montserrAt n, nivet e, sAnCho-mArtínez i, hishidA t, KumAr s, miquel l et Al.. Reprogram-
ming of human fibroblasts to pluripotency with lineage specifiers.Cell Stem Cell.

2013 Sep 5;13(3):341-50.

• Gu y, liu Gh, PlonGthonGKum n, Benner C, yi F, qu J et Al.. Global DNA methylation and
transcriptional analyses of human ESC-derived cardiomyocytes.Protein Cell. 2013

Aug 27;.

• mArti m, montserrAt n, PArdo C, mulero l, miquel-serrA l, CAvACo rodriGues Am et Al..
M-cadherin-mediated intercellular interactions activate satellite cell division.J Cell
í
Sci. 2013 Nov 15;126(Pt 22):5116-31.

Highlights
TheCMR[B] isaresearchcentrefocusedontheinvestigationofthemechanisms
that regulate cell differentiation and patterning during development and regenera-

tion. In the same manner, the general activity of the center is orientated towards
á
the research in regenerative medicine, with special emphasis in the generation of
patient-derived induced pluripotent stem cells (iPSCs) for disease modelling. Our

goal is to define efficient protocols for the differentiation of mesenchymal stem ú

cells (MSCs) from human tissues (adipose and bone marrow tissues) and iPSCs
towards bone, cartilage, retinal pigmented epithelial cells, hematopoietic cells
ú
and cardiac muscle cells. Our newly defined protocols include the use of soluble
factors, chemically defined media, biomatrices and tissue-specific genes.

In order to accomplish our aims we have been working in collaboration with Dr. á

Ivon Cusco from the CIBERER.

Besides, we have been collaborating with Dr. Elena Martínez (IBEC; CIBER-BBN),

and from the CMR[B] we supervised a short stay of the predoctoral student Albert
Garca. This collaboration culminated in the presentation of a poster at the 6th

IBEC Symposium on Bioengineering and Nanomedicine (8/5/2013, Barcelona):

• Extended microcontact printing technique for the patterning of soft substrates:
application to stem cell differentiation. Albert García, Verónica Hortigüela, Car-

me Cortina, Anna Lagunas, Josep Samitier, Nuria Montserrat, Elena Martínez

Two other posters were presented in this Symposium:
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• Transdifferentiation of human Fibroblasts to cardiac fate. Lorena de Oñate, ú

Montserrat Barragn, Nria Montserrat, Juan Carlos Izpisa
13
20
• Generation of cardiac human reporter cell lines with BACs engineered by I- T
éOR
SceI stimulated recombineering methods. Lorena de Oate, Rubn Peco, Núria P
Montserrat, Juan Carlos Izpisa
RE
L
These posters were also presented at the VII Jornadas Anuales CIBER BBN held A
NU
on 21-22/11/2013, Torremolinos, Mlaga.
N
A
INDEXED PUBLICATIONS N /
B
34 articles, 25 of them, published in scientific journals ranked in the first quartile.
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R
BE
CI

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