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Most relevant scientific articles
• Puras g., Mashal M., zarate J., agirre M., oJeDa e., griJalVo s. et al . A novel cationic niosome formula- tion for gene delivery to the retina . Journal of Controlled Release . 2014; 174(1):27-36 .
• esCorihuela J., Banuls M.-J., griJalVo s., eritJa r., PuChaDes r., Maquieira a. Direct covalent attachment of DNA microarrays by rapid thiol-ene “click” chemistry . Bioconjugate Chemistry . 2014; 25(3):618-627 .
• griJalVo s., alagia a., Puras g., zarate J., PeDraz J.l., eritJa r. Cationic vesicles based on non-ionic sur- factant and synthetic aminolipids mediate delivery of antisense oligonucleotides into mammalian cells . Colloids and Surfaces B: Biointerfaces . 2014; 119:30-37 .
• aVino a., Portella g., Ferreira r., gargallo r., Mazzini s., gaBeliCa V. et al . Specific loop modifications of the thrombin-binding aptamer trigger the formation of parallel structures . FEBS Journal . 2014; 281(4):1085-1099 .
• tintoré M., eritJa r., FaBrega C. DNA nanoarchitectures: Steps towards biological applications . Chem- BioChem . 2014;15(10):1374-1390 .
Highlights
Institution: Agencia Estatal Consejo Superior De Investigaciones Científicas Contact: Instituto de Química Avanzada de Cataluña, CSIC . C/ Jordi Girona, 18-26 . 08034 Barcelona . Teléfono: (+34) 93 400 61 45 · E-mail: recgma@cid .csic .es http://www .iqac .csic .es/index .php?option=com_ogngrups&view=detall_grup&Itemid=95&cid=47&lang=es
In collaboration with other CIBER-BBN (NANOBIOCEL, NN-UMH) groups we have developed formulations for transfection of nucleic acids that are effective for gene therapy of ocular diseases . With these results we have obtained a project (Retos-Colaboración, TERET) . Also in collaboration with other CIBER-BBN (NBT-UAB, GOA-HSCSP) groups we have obtained nanoconjugates directed against cancer stem cells that are able to effectively remove metastatic cells . We have requested several projects based on these results that are under evaluation . Also in collaboration with a group of the Polytechnic University of Valencia (UPV) we have achieved a method for immobilizing DNA probes based on the radical reaction between thiols and alkenes . This methodology allows the preparation of devices for the detection of mutations . The results have been protected by a patent application . An important part of scientific activity has been focused on the evaluation of small RNA (siRNA) duplexes that are capable of silencing genes specifically . We have studied the introduction of small chemical modifications that increase the stability of siRNAs in serum and the ability to use nanostructured materials (prepared by other groups CIBER-BBN) for the development of new formulations that increase the efficiency of transfection . In collaboration with the group of CIBER-BBN (ICN2-CSIC) we have studied the detection of microRNA by SPR using capture probes with high efficiency which are able to form triple helices with the target miRNA . We have also studied a series of compounds for their potential ability to inhibit DNA repair enzymes that can be used to increase the efficacy of chemotherapy . Finally structural details and possible applications of G-quadruplex forming oligonucleotides have been studied .
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