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Most relevant scientific articles
• Morral-ruiz g., Melgar-lesMes P., garCia M.l., solans C., garCía-CelMa M.J. Polyurethane and polyu- rea nanoparticles based on polyoxyethylene castor oil derivative surfactant suitable for endovascular applications . International Journal of Pharmaceutics . 2014;461(1-2):1-13 .
• ahMaD n., raMsCh r., llinas M., solans C., hashiM r., taJuDDin h .A . Influence of nonionic branched-chain alkyl glycosides on a model nano-emulsion for drug delivery systems . Colloids and Surfaces B: Bioin- terfaces . 2014;115:267-274 .
• VilChez a., roDriguez-aBreu C., Menner a., BisMarCk a., esquena J. Antagonistic effects between magneti- te nanoparticles and a hydrophobic surfactant in highly concentrated pickering emulsions . Langmuir . 2014;30(18):5064-5074 .
• Melgar-lesMes P., Morral-ruiz g., solans C., garCía-CelMa M.J . Quantifying the bioadhesive properties of surface-modified polyurethane-urea nanoparticles in the vascular network . Colloids and Surfaces B: Biointerfaces . 2014;118:280-288 .
• siriViriyanun a., iMae t., CalDero g., solans C. Phototherapeutic functionality of biocompatible graphene oxide/dendrimer hybrids . Colloids and Surfaces B: Biointerfaces . 2014;121:469-473 .
Highlights
Institution: Agencia Estatal Consejo Superior de Investigaciones Científicas Contact: Instituto de Química Avanzada de Cataluña, CSIC · C/ Jordi Girona, 18-26 . 08034 Barcelona Teléfono: (+34) 93 400 61 59 . E-mail: csmqci@cid .csic .es · Website: http://www .iqac .csic .es/qci
The research activities have mainly focused to the design, characterization and functionalization of advanced multifunctional polymeric nanoparticles for the therapy of neurodegenerative diseases per- formed in the frame of the CIBER-BBN intramural project “Novel nanocarriers as delivery systems across the Blood-Brain barrier”(Nano3B) . The nanoparticles, with sizes below 100 nm, have been prepared by nano-emulsion templating using low-energy methods . This technology, developed in our group, allows nanoparticle size control and high drug entrapment efficiency using biocompatible components . Mo- reover, it can be performed under mild processing conditions (e .g . at low temperature, 25oC, allowing the preservation of pharmacological properties of molecules chemically unstable at high temperature), requires simple equipment and it is easily scalable . The nanoparticles have been functionalized with self- penetrating peptides and monoclonal antibodies for the specific blood-brain barrier (BBB) targeting and encapsulated with specific drugs to treat X-linked adrenoleukodystrophy (X-ALD) disease . In addition, in vitro and in vivo evaluation of the drug–loaded functionalized nanoparticles has been performed . The results have showed that the designed nanoparticles are appropriate for the intended application . The group has also performed research activities in the frame of the following projects: “Multifunctional na- notechnology for selective detection and treatment of cancer” (FP7-NMP-2010-LARGE-4; C-NMP/0878), “Studies on amphiphile self-assembly processes and technologies for eco-friendly and biocompatible applications” (CTQ2011-29336-C03) and “Formation of Pickering emulsions by low-energy methods for the preparation of new porous nanostructured materials” (CTQ2011- 23842) . The most important outcomes of the results obtained are reflected in 21 indexed publications, as well as in the presentation of 13 (one of them invited) oral and 18 poster presentations in national and international conferences . Two PhD thesis and 1 Master thesis have been presented .
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