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Most relevant scientific articles
• Frigell J., garCía i., góMez-ValleJo V., lloP J., PenaDés s . 68Ga-labeled gold glyconanoparticles for explo- ring blood-brain barrier permeability: Preparation, biodistribution studies, and improved brain uptake via neuropeptide conjugation . Journal of the American Chemical Society . 2014;136(1):449-457 .
• ChioDo F., MarraDi M., Park J., raM a.F.J., PenaDés s., Van Die i. et al . Galactofuranose-coated gold nanoparticles elicit a pro-inflammatory response in human monocyte-derived dendritic cells and are recognized by DC-SIGN . ACS Chemical Biology . 2014;9(2):383-389 .
• CanDiota a.P., aCosta M., siMoes r.V., DelgaDo-goni t., loPe-PieDraFita s., irure a. et al . A new ex vivo method to evaluate the performance of candidate MRI contrast agents: A proof-of-concept study . Journal of Nanobiotechnology . 2014;12(1) .
• etXeBarría J., CalVo J., reiCharDt n.-C. Nanostructured weathering steel for matrix-free laser desorp- tion ionisation mass spectrometry and imaging of metabolites, drugs and complex glycans . Analyst . 2014;139(11):2873-2883 .
• Murray r.a., qiu y., ChioDo F., MarraDi M., PenaDés s., Moya s.e. A quantitative study of the intracellular dynamics of fluorescently labelled glyco-gold nanoparticles via fluorescence correlation spectroscopy . Small . 2014;10(13):2602-2610 .
Highlights
Institution: CIC biomaGUNE Contact: CIC biomaGUNE · Parque Tecnológico de San Sebastián . Po Miramón, 182 . Ed . Empresarial C . 20009 San Sebastián · Tel .: +34 943 005 328 · E .mail: spenades@cicbiomagune .es Website: http://www .cicbiomagune .es/secciones/investigacion/ficha_laboratorio .php?idioma=en&unidad= 1&subgrupo=2&subseccion=unidades_investigacion
The year 2014 was especially important to strengthen the research of the group towards translational medicine .
The group of Niels-Christian Reichardt at CIC biomaGUNE has developed the CarboQuant platform technology for absolute glycan quantifition by mass spectrometry . The patented technology is based on the preparation and use of stable isotope labeled glycans as internal standards . Applications include clinical diagnosis and quality control for the development and production of biopharmaceuticals . A market study has been made and a business plan written to prepare for the commercialization of the technology via a spin-off company which is planned for March 2015 .
Based on the CarboQuant technology two kits for quantitative glycan profiling employing MALDI-Tof MS termed mAbsolute have been developed and validated . These kits, and a quantification software are currently being tested in a pilot study for their use in biopharmaceutical quality control by Roche/ Germany and MSD/The Netherlands . A dedicated kit will be employed in a first clinical diagnostics study with Leiden/The Netherlands University Medical Center .
IMMUNOSHAPE, coordinated by Niels-Christian Reichardt is a Marie Curie European Training Network which brings together 14 leading European partners in a transnational network, implementing a multi- disciplinary and multisectorial research and training programme between academic and industrial part- ners in the fields of biomedical glycoscience and its industrial applications . IMMUNOSHAPE aims at training a new generation of scientists that will be capable to develop new lead structures for highly selective glycan based multivalent immunotherapeutics with clinical applications .
Midatech Biogune S .L ., part of the Midatech Pharma group, has completed the refit of its plant in Bil- bao . The aim was to adapt the installations and infrastructure in order to allow manufacture of its nano medicine products in the pre-clinical phase in sterile conditions . “Project financed by the Ministry of Economy and Competition, through the program EQUIPA 2014” .
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