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Most relevant scientific articles
• alMenDros i., Wang y., BeCker l., lennon F.e., zheng J., Coats B.r. et al . Intermittent hypoxia-induced changes in tumor-associated macrophages and tumor malignancy in a mouse model of sleep apnea . American Journal of Respiratory and Critical Care Medicine . 2014;189(5):593-601 .
• isetta V., leon C., torres M., eMBiD C., roCa J., naVaJas D . et al . Telemedicine-based approach for obstruc- tive sleep apnea management: Building evidence . Journal of Medical Internet Research . 2014;16(2) .
• anDreu i., luque t., sanCho a., PelaCho B., iglesias-garCía o., Melo e. et al . Heterogeneous microme- chanical properties of the extracellular matrix in healthy and infarcted hearts . Acta Biomaterialia . 2014;10(7):3235-3242 .
• Martínez-garCía M.-a., Martorell-CalatayuD a., nagore e., Valero i., selMa M.J., Chiner e. et al . Associa- tion between sleep disordered breathing and aggressiveness markers of malignant cutaneous mela- noma . European Respiratory Journal . 2014;43(6):1661-1668 .
• Moreno-inDias i, torres M, Montserrat JM, sanChez-alCoholaDo l, CarDona F, tinahones FJ et al . Intermit- tent hypoxia alters gut microbiota diversity in a mouse model of sleep apnoea .The European respira- tory journal . 2014 .
Highlights
Institution: Universidad de Barcelona Contact: Facultad de Medicina . C/ Casanova 143 . 08036 Barcelona . Teléfono: (+34) 93 402 45 15 E-mail: dnavajas@ub .edu · Website: http://www .ub .edu/biofisica
The research activity of the group has an interdisciplinary and translational character, integrating basic and clinical aspects . In 2014 the research has focused mainly on the corporate programs “Sleep Apnea- Hypopnea Syndrome” (SAHS) and “Acute Lung Injury” (ALI) . In the first program we have obtained very significant achievements in the study of the relationship between cancer and SAHS . We have established that there is increased cancer mortality in patients with SAHS, that SAHS enhances human malignant melanoma and we have shown that the immune system plays an important role in cancer- related SAHS . We have also shown that telemetric tools are useful for diagnosing and home monitoring of SAHS . We have developed research contracts with companies to improve instrumentation equipment for SAHS therapy . In animal models we have determined that age induces significant changes in brain response to apneas and male fertility is greatly reduced by the intermittent hypoxia of SAHS . In ALI we have used tissue engineering tools to advance the understanding of the basic mechanisms of lung regeneration/repair . Using nano- and micro-technologies we first described local changes in rigidity of the extracellular matrix in normal and fibrotic lungs . These results will allow understanding cell-matrix interaction in lung regeneration . We have characterized the local viscoelasticity of normal and fibrotic cardiac tissue, which is relevant to understand cardiac remodeling in pulmonary hypertension . We have also studied the mechanical changes induced in pulmonary extracellular matrix by freezing/thawing and sterilization of the lung tissue . We also described for the first time that the partial pressure of oxygen enhances physiological differentiation of stem cells into lung epithelial phenotypes, being relevant for the optimization of lung regeneration .
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