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• B FJ, r-r C. New targets for disease modifying osteoarthritis drugs:
Most relevant lAnCouizomero
chondrogenesis and Runx1. Ann Rheum Dis. 2013 May;72(5):631-4.
scientific
• mAGAlhães J, sousA rA, mAno JF, reis rl, BlAnCo FJ, sAn román J. Synthesis and charac-
articles
terization of sensitive hydrogels based on semi-interpenetrated networks of poly[2-
ethyl-(2-pyrrolidone) methacrylate] and hyaluronic acid. J Biomed Mater Res A.

2013 Jan;101(1):157-66.

• mAteos J, de lA Fuente A, lesende-rodríGuez i, Fernández-PernAs P, AruFe mC, BlAnCo FJ.
Lamin A deregulation in human mesenchymal stem cells promotes an impairment

in their chondrogenic potential and imbalance in their response to oxidative stress.
Stem Cell Res. 2013 Nov;11(3):1137-48.

• C C, m-l e, h-G t, F-B i, d-P s, B FJ.
iCioneuiñosóPezermidAómezuentesoqueteíAzrAdolAnCo
Effects of severe hypoxia on bone marrow mesenchymal stem cells differentiation
potential. Stem Cells Int. 2013;2013:232896.

• m md, C-F P, G-F r, m--i o, W hz,
AyAnArPinteroernándezAGouentesArtínezdelArduyAAnG
vAliunAs v et Al.. Human articular chondrocytes express multiple gap junction pro-

teins: differential expression of connexins in normal and osteoarthritic cartilage. Am
J Pathol. 2013 Apr;182(4):1337-46.

During 2013, GBTTC-CHUAC group has published 12 peer-reviewed articles in
Highlights
which are described new regulators and the effect of biophysical stimuli, such as

oxygen tension, in the differentiation of mesenchymal stem cells; the synthesis
and characterization of hybrid hydrogels for their application in cartilage tissue

engineering; and it was demonstrated that adults human chondrocytes commu-

nicate through gap junctions formed by connexin 43 and that the levels of this
protein are expressed in a cartilage zonal structure-dependent manner which

could affect the functional integrity of chondrocytes.

Moreover GBTTC-CHUAC group has generated 6 procedures, methodologies or te-
chniques that affect processes of prevention, diagnosis and treatment of osteoar-

thritis such as the pharmacoproteomics of chondroitin culfate in osteoarthritis

therapy; the use of biomarkers for the purposes of diagnosis and drug discovery
programs, medical applications of hydrogen sulfide and the use of the human

amniotic membrane as a potential tissue and cell source in the repair of cartilage
lesions. The latest work has been prize awarded in the XIII Congress of the Spa-

nish Association of Tissue Banking.

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